Here, for example, the single difference in the sequences can be eliminated (red for blue or vice versa). That is the recognition sequences are short string of identical bases on both DNA strands. These enzymes predictably cut both strands because the sequences they recognize are palindromic. Repairs can then be made (probably by the mechanism of homologous recombination). Palindromic Sequences Restriction enzymes cut double-stranded DNA at specific locations based the pattern of bases found at those locations. All that is needed is to form a loop so that the two sequences line up side-by-side. This orientation and redundancy may help ensure that a deleterious mutation in one copy of the set can be repaired using the information in another copy of that set. (The dashes represent the thousands of base pairs that separate adjacent palindromes.) The human Y chromosome contains 7 sets of genes - each set containing from 2 to 6 nearly-identical genes - oriented back-to-back or head-to-head that is, they are inverted repeats like the portion shown here. Introduction As the exploration of various genomes, including our own, moves forward thanks to ever more advanced and more easily available techniques, it is becoming clear that the genome is much more than the assembly of genes. Many international consortia provide a comprehensive description of common genetic variation making alternative sequence. Inverted repeats are found in both prokaryotic and eukaryotic genomes and they have been linked with countless possible functions. Inverted repeats at either end of retroviral gene sequences aid in inserting the DNA copy into the DNA of the host. Background An inverted repeat is a DNA sequence followed downstream by its reverse complement, potentially with a gap in the centre.The DNA of many transposons is flanked by inverted repeats such as this one:ĥ' GGCCAGTCACAATGG.~400 nt.CCATTGTGACTGGCC 3'ģ' CCGGTCAGTGTTACC.~400 nt.GGTAACACTGACCGG 5'.Transcription factors are often dimers of identical proteins homodimers so it is not surprising that each member of the pair needs to 'see' the same DNA sequence in the same orientation. The DNA sequence shown above is that of the glucocorticoid response element where n represents any nucleotide. An example of this is shown in the diagram. Some restriction enzymes recognize a section of DNA that is the same sequence read 53 on one strand as it is read 53 on the complementary strand. The DNA to which transcription factors bind. Question: Which of the following would be an example of a palindromic DNA sequence: 3- GTTAAG-5' O 5- CAATTC-3' 3- CTTAAC-5 O 5- CTTAAC-3 3- CTTTTG-5 O 5' - GAAAC-3 3 - CTTAAG-5 5' - GAATTC-3 O 3' - CTTCCT - 5 5' - GAAGGU - 3 In the process of DNA replication the Okazaki fragment can best be described as Short segments of nucleic. Question Video: Recognizing Palindromic Sequences.

In these cases, two different segments of the double helix read the same but in opposite directions.

Palindrome dna sequence example